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Persistent sad, anxious or "empty" mood
Feelings of hopelessness or pessimism
Feelings of guilt, worthlessness or helplessness
Loss of interest or pleasure in activities that were once enjoyed, including sex
Appetite loss and/or weight loss
Overeating and weight gain
Decreased energy, fatigue, feeling "slow"
Insomnia, early morning awakening, or oversleeping
Thoughts of death or suicide, or suicide attempts
Restlessness and/or irritability
Difficulty concentrating, remembering, making decisions
Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain
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